CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 60 enrolled
Drug / intervention
2.5% flurbiprofen +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06041178
NCT06041178Phase 4Completed
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Efficiency of Flurbiprofen 2.5% in Comparison to 98% Aloe Vera Gel as an Adjunctive Therapy to Scaling and Root Planning in the Initial Treatment of Stage III Chronic Periodontitis in Smoking Patients

Beirut Arab University·interventional·Posted Sep 18, 2023·Updated Sep 18, 2023

In Brief

A Phase 4 clinical trial evaluating 2.5% flurbiprofen, 98% aloe vera, and 1 other intervention for Periodontitis Chronic Generalized Severe. Completed, enrolled 60 participants across 1 site.

Detailed Summary

This study aims to evaluate clinically the efficacy of flurbiprofen gel in comparison to Aloe Vera gel as adjunctive to SRP in the reduction of periodontal pockets in patients with chronic periodontitis in smoking patients. All patients will receive SRP prior to treatment. * Group 1: one site will receive flurbiprofen while the contralateral site will receive a placebo * Group 2: one site will receive aloe vera while the contralateral site will receive a placebo * Group 3: one site will receive flurbiprofen while the contralateral site will receive aloe vera Researchers will compare the inter and intra-groups differences to check if there's a variation in the periodontal parameters measured.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPeriodontitis Chronic Generalized Severe
CountriesLebanon
Collaborators--

Timeline

Phase 4CompletedFinished
2023202420252026
First PostedSep 18, 2023
Enrollment StartSep 30, 2022
Primary CompletionMay 25, 2023
Study CompletionJul 19, 2023
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 2.8 years ago

Interventions

2.5% flurbiprofendrug

Gel was made of 20% poloxamer and 10% ethanol as an Optimum formulation with sustained release up to 48 hours and a reasonable sol gel transition phase (adjunctive to SRP)

98% aloe veradrug

the Aloe vera gel employed possessed a concentration of 98% and was obtained from the reputable brand Avivir (Denmark). The remaining 2% comprised normal saline. The process of obtaining the 98% Aloe vera gel involved meticulous washing of mature Aloe Vera leaves under running water, followed by the removal of their outer skin. Subsequently, each leaf was divided into smaller pieces, from which the gel was allowed to seep out and carefully collected in a sterile container. The collected gel was then stored at 4°C until the time of its application in the study (adjunctive to SRP)

Placeboother

saline