At a glance
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Neuroinflammatory Mechanisms Linking Chronic Stress to Motivational Deficits
In Brief
A Phase 4 clinical trial evaluating Minocycline and Placebo for Stress, Psychological and Motivation. Completed, enrolled 10 participants across 1 site.
Detailed Summary
Motivational deficits such as anhedonia are core to several psychiatric disorders and underlie significant functional impairment. This double-blind, placebo-controlled crossover trial of minocycline, an anti-\[neuro\]inflammatory agent, examines links between chronic stress and responses to a reward-related motivation task. It will evaluate the effects of pharmacologically attenuating neuroinflammation on behavioral responses to a reward-related motivation task in individuals experiencing unemployment. Understanding the effects of neuroinflammation on reward function among individuals experiencing chronic stress represents a critical first step in identifying novel neuroimmune targets for future clinical trials.
Study Details
Timeline
Interventions
Participants will take 2 pills of 100 mg totaling a 200 mg dose of minocycline per day.
A placebo is a sugar pill that has no therapeutic effect and will be administered orally. Participants will receive 2 placebo tablets matching the Minocycline tablets daily for 5 days.