CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 46 enrolled
Drug / intervention
Regular Nicotine patch and lozenge dose +1 moredrug
Likely dose
Regular Nicotine patch and lozenge dose 1mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06087328
NCT06087328Phase 2Completed

Comparing the Effects of Augmented Doses of Nicotine Replacement Therapy on Quitting Cigarettes and E-cigarettes

Medical University of South Carolina·interventional·Posted Oct 17, 2023·Updated Nov 26, 2025

In Brief

A Phase 2 clinical trial evaluating Regular Nicotine patch and lozenge dose and Augmented Nicotine patch and lozenge dose for Smoking Cessation and 2 related conditions. Completed, enrolled 46 participants across 1 site.

Detailed Summary

Many people smoke cigarettes and use e-cigarettes, and have a hard time stopping. Nicotine replacement therapy medications, such as nicotine patches and lozenges, have been shown to help people quit e-cigarette use. The purpose of the present study is to see how well nicotine patches and lozenges help people quit both smoking and vaping, and to determine if higher doses of the medication work best.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2CompletedFinished
202420252026
First PostedOct 17, 2023
Enrollment StartDec 5, 2023
Primary CompletionNov 5, 2024
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 2.7 years ago

Interventions

Regular Nicotine patch and lozenge dosedrug

1mg patch, qd + 4mg lozenge prn \[minimum of 5 \& up to 20 per day\]

Augmented Nicotine patch and lozenge dosedrug

21mg patch + 14mg patch qd + 4mg lozenge prn \[minimum of 5 \& up to 30 per day\] OR 2 x 21mg patches qd + 4mg lozenges prn \[minimum of 5 \& up to 40 per day\]