CI

At a glance

ClinicalIndex Comparison Record
Phase 2Active· 147 enrolled
Drug / intervention
Pembrolizumab (+) Berahyaluronidase alfa +1 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06099782
NCT06099782Phase 2Active

A Phase 2 Study to Evaluate Patient Reported Preference for Subcutaneous Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) Over Intravenous Pembrolizumab Formulation in Participants With Multiple Tumor Types (MK-3475A-F11)

Merck Sharp & Dohme LLC·interventional·Posted Oct 25, 2023·Updated Apr 8, 2026

In Brief

A Phase 2 clinical trial evaluating Pembrolizumab (+) Berahyaluronidase alfa and Pembrolizumab for Non-Small Cell Lung Cancer and 2 related conditions. Active but no longer recruiting, targeting 147 participants across 45 sites in 10 countries.

Detailed Summary

The purpose of this study is to evaluate participant preference for coformulated hyaluronidase/pembrolizumab pembrolizumab (+) berahyaluronidase alfa \[MK-3475A\] administered subcutaneously (SC) over pembrolizumab \[MK-3475\] administered intravenously (IV) in participants with multiple tumor types. There will be no hypothesis testing in this study.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesArgentina, Australia, Chile, France, Japan, New Zealand, Poland, South Africa, Turkey (Türkiye), United States
Collaborators--

Timeline

Phase 2Active
2024202520262027
First PostedOct 25, 2023
Enrollment StartDec 26, 2023
Primary CompletionApr 9, 2025
Study CompletionFeb 15, 2027
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 2.7 years ago

Interventions

Pembrolizumab (+) Berahyaluronidase alfabiological

Fixed dose coformulated product of hyaluronidase/pembrolizumab adminstered via SC injection.

Pembrolizumabbiological

Administered via IV infusion