At a glance
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The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral Total Knee Arthroplasty: a Randomized Controlled Trial
In Brief
A clinical study evaluating primary unilateral TKA, Bupivacain, and 5 other interventions for Arthritis Knee and 2 related conditions. Completed, enrolled 80 participants across 1 site.
Detailed Summary
This interventional study aims to compare the effectiveness of local multimodal drug periarticular injection in TKA patients with the standard pain control regime that includes opioids, NSAIDs, and other analgesics. The main questions The investigators strive to answer are: Is there a significant difference in the severity of pain and functional outcomes when applying periarticular injections? Are there any increased complications when applying the periarticular injections?
Study Details
Timeline
Interventions
Primary unilateral total knee arthroplasty with cruciate scarifying cemented DePuy Synthes PFC Sigma prosthesis.
low body weight (0.50%, 20cc) intraoperative periarticular injection
1ml of 30mg/ml ketorolac intraoperative periarticular injection
0.5ml Adrenaline 1mg/ml intraoperative periarticular injection
IV Paracetamol \[Ofirmev\] introduced every 6 hours after surgery
IV Ketorolac {Toradol} introduced every 12 hours after surgery.
IV Tramadol \[Ultram\] introduced when needed after surgery