CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 10 enrolled
Drug / intervention
Hypericin +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06149247
NCT06149247Phase 2Completed

Pilot Study of HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment of CTCL

Soligenix·interventional·Posted Nov 28, 2023·Updated Aug 20, 2025

In Brief

A Phase 2 clinical trial evaluating Hypericin and Mechlorethamine Topical Gel for Cutaneous T-Cell Lymphoma/Mycosis Fungoides. Completed, enrolled 10 participants across 1 site.

Detailed Summary

The objective of this clinical study is to compare the safety and effectiveness of Valchlor versus HyBryte following 12 weeks of treatment.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
202420252026
First PostedNov 28, 2023
Enrollment StartDec 5, 2023
Primary CompletionMay 31, 2024
Study CompletionJun 27, 2024
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 2.6 years ago

Interventions

Hypericindrug

HyBryte is synthetic hypericin formulated as a 0.25% hypericin ointment.

Mechlorethamine Topical Geldrug

Valchlor is an FDA-approved drug for the treatment of CTCL.