CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 79 enrolled
Drug / intervention
Simultaneous administration of vasopressors +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06155812
NCT06155812Phase 3Completed

Simultaneous Administration of Norepinephrine, Angiotensin II, and Vasopressin in Septic Shock Patients

University Medical Centre Maribor·interventional·Posted Dec 4, 2023·Updated Mar 31, 2026

In Brief

A Phase 3 clinical trial evaluating Simultaneous administration of vasopressors and Successive administration of vasopressors for Shock, Septic. Completed, enrolled 79 participants across 2 sites in 2 countries.

Detailed Summary

The goal of this prospective randomized controlled trial is to compare the effects of classic stepwise vs. early balanced multimodal vasopressor strategies in septic shock.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsShock, Septic
CountriesCroatia, Slovenia
Collaborators--

Timeline

Phase 3CompletedFinished
202420252026
First PostedDec 4, 2023
Enrollment StartDec 23, 2023
Primary CompletionDec 31, 2025
Study CompletionFeb 1, 2026
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 2.6 years ago

Interventions

Simultaneous administration of vasopressorsother

Early, simultaneous administration of norepinephrine, angiotensin II, and vasopressin.

Successive administration of vasopressorsother

Administration and titration of norepinephrine and vasopressin. Administration of additional vasoactive drugs (epinephrine, methylene blue, angiotensin II or dopamine) as per clinical team. Initiation of inotropes (dobutamin, levosimendan, milrinone) as per clinical team decision.