CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 921 enrolled
Drug / intervention
Ploom HTP Menthol HTS; MX3 (681) +3 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06179290
NCT06179290N/ACompleted
CompareCT.gov

A Multi-site, Open-Label, Parallel-Group Study To Evaluate Changes In Tobacco-Related Biomarkers of Exposure and Biomarkers of Potential Harm With Use of Heated Tobacco Products Compared to Combustible Cigarettes in Adult Smokers

Altria Client Services LLC·interventional·Posted Dec 21, 2023·Updated May 27, 2026

In Brief

A clinical study evaluating Ploom HTP Menthol HTS; MX3 (681), Ploom HTP Tobacco HTS; R8 (120), and 2 other interventions for Tobacco Use. Completed, enrolled 921 participants across 8 sites.

Detailed Summary

The purpose of the study is to evaluate changes in biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs) in adult smokers who completely switch to Ploom heated tobacco products (HTPs) compared to those who continue to smoke usual brand combustible cigarettes (UBCC).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTobacco Use
CountriesUnited States
CollaboratorsCelerion

Timeline

N/ACompletedFinished
202420252026
First PostedDec 21, 2023
Enrollment StartOct 2, 2023
Primary CompletionMay 15, 2024
Study CompletionMar 24, 2025
TodayJul 2, 2026
Enrollment to primary: 7 monthsPosted 2.5 years ago

Interventions

Ploom HTP Menthol HTS; MX3 (681)other

Menthol heated tobacco product

Ploom HTP Tobacco HTS; R8 (120)other

Non-menthol heated tobacco product

Smoking Abstinence (menthol)other

No smoking or other tobacco product use for duration of the study, menthol group comparator

Smoking Abstinence (non-menthol)other

No smoking or other tobacco product use for duration of the study, non-menthol group comparator