At a glance
ClinicalIndex Comparison Record- ✓Pelvic or thoracic tumors with indication for radiotherapy
- ✓Age ≥18 years
- ✓Informed consent provided
- ✕Prior radiotherapy at affected site
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Pelvic and Thoracic Cancer Treated With Online Adapted Radiotherapy: A Prospective Registry-based Phase-II Trial
In Brief
An observational study for Pelvic Tumor and Thoracic Tumor. Currently recruiting, targeting 846 participants across 1 site.
Detailed Summary
This prospective registry-based trial will include patients with pelvic or thoracic tumors with an indication for radiotherapy treated with oART or IGRT. For the primary endpoint and the secondary clinical endpoints, the trial will compare oART versus IGRT, for technical endpoints the trial will compare the real oART scenario with two virtual (hypothetical) control scenarios. Primary endpoint: * 10% reduction in the rate of acute radiotherapy related toxicity (≥ CTCAE II°, v5.0) using oART Secondary endpoints: * Clinical endpoints: Tumor control, late toxicities compared to conventional irradiated patients, quality of life and patient-reported outcomes * Technical endpoints: Target volume, target coverage, dose to organs at risk, anatomical variability score