CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 22 enrolled
Drug / intervention
VH4524184 +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06214052
NCT06214052Phase 2Completed

A Phase 2a, Randomized, Double-Blind (Sponsor Unblinded), Placebo-Controlled, Study to Investigate the Antiviral Effect, Safety, Tolerability and Pharmacokinetics of VH4524184 in HIV-1 Infected Treatment Naïve Adults

ViiV Healthcare·interventional·Posted Jan 19, 2024·Updated Jun 29, 2025

In Brief

A Phase 2 clinical trial evaluating VH4524184, Matching Placebo, and 1 other intervention for HIV Infections. Completed, enrolled 22 participants across 17 sites in 5 countries.

Detailed Summary

The purpose of this study is to evaluate the safety, tolerability, ability of VH4524184 when given alone to reduce the amount of HIV (viral load) in people with HIV-1 infection who have never received antiretroviral therapy (treatment-naïve). Data from this study will be used to decide how VH4524184 can be best included in a full-treatment regimen for HIV-1 in the future.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHIV Infections
CountriesArgentina, Canada, Italy, Spain, United States
CollaboratorsGlaxoSmithKline

Timeline

Phase 2CompletedFinished
202420252026
First PostedJan 19, 2024
Enrollment StartFeb 7, 2024
Primary CompletionJun 12, 2024
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 2.5 years ago

Interventions

VH4524184drug

VH4524184 was administered as tablets orally at Day 1.

Matching Placebodrug

VH4524184 Matching Placebo was administered as tablets orally at Day 1.

Antiretroviral therapydrug

Antiretroviral therapy was administered as available and as per investigator's recommendation.