CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 26 enrolled
Drug / intervention
High-flow nasal cannula device with flow setting at 40 L/min or higherdevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06228703
NCT06228703N/ACompleted

The Effects of Different Flow Settings on Lung Impedance Using Two New HFNC Devices: A Randomized Crossover Study on Healthy Volunteers

Rush University Medical Center·interventional·Posted Jan 29, 2024·Updated Dec 19, 2025

In Brief

A clinical study evaluating High-flow nasal cannula device with flow setting at 40 L/min or higher for Healthy. Completed, enrolled 26 participants across 1 site.

Detailed Summary

This prospective, randomized crossover trial will enroll adult healthy volunteers. Initially, the subject's peak inspiratory flow will be measured using a mask connected with a respiratory monitor. Subsequently, the volunteers will undergo HFNC treatment at different flow settings while their peak inspiratory flow will be continuously monitored. The primary outcome of this study is the lung aeration with different flow settings. Secondary outcomes include the lung aeration with different devices, subject's comfort at different flow settings, and the correlation between the subject's peak inspiratory flow measured by HFNC and by a mask connected with a respiratory monitor.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHealthy
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
202420252026
First PostedJan 29, 2024
Enrollment StartMay 19, 2024
Primary CompletionOct 15, 2024
Study CompletionOct 26, 2024
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 2.4 years ago

Interventions

High-flow nasal cannula device with flow setting at 40 L/min or higherdevice

Eligible participants will use the high-flow nasal cannula device (Airvo3 or HFT 750) with flow set at 40 L/min or higher