At a glance
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The Impact of Gluten-free Diet on the Thyroid Function, Quality of Life and Gut Microbiome Composition in Women With Autoimmune Thyroiditis
In Brief
A clinical study evaluating Gluten-free diet, Gluten capsules supplementation, and 1 other intervention for Autoimmune Thyroiditis. Completed, enrolled 31 participants across 1 site.
Detailed Summary
The purpose of this interventional study was to check if the elimination of gluten from the diet of women with autoimmune thyroiditis affects their health and thyroid function, quality of life, and the gut microbiome composition. The main questions it aimed to answer were: * Does the gluten-free diet worsen the gut microbiome composition? * Does the gluten-free diet improve thyroid function, measured as thyroid stimulating hormone (TSH), thyroid hormones thyroxine (FT4) and triiodothyronine (FT3), thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb)? * Does the gluten-free diet improve the quality of life? Participants: * followed normocaloric gluten-free diet for 8 weeks * after first 4 weeks were randomly assigned to one of two groups. One group over next 4 weeks additionally to gluten-free diet received gluten in gastrosoluble capsules and second group - rice starch (placebo). Blood and stool samples were collected before diet (T0), after 4 weeks (T1) and after 8 weeks of diet (T2) (total of 3 samples per participant). Also each participant completed the ThyPROpl quality of life assessment questionnaire for patients with thyroid diseases in three time points: before the diet (T0), after 4 weeks (T1) and after 8 weeks of the diet (T2).
Study Details
Timeline
Interventions
Diet with gluten elimination followed by all participants for 8 weeks
2 g of gluten given in 3 capsules daily for 4 weeks (week 5 to week 8)
Rice starch in gastrosoluble capsules given in 3 capsules daily for 4 weeks (week 5 to week 8).