CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 73 enrolled
Drug / intervention
Placebo (placebo matching zibotentan capsule and placebo matching dapagliflozin tablet) +2 moredrug
Likely dose
Zibotentan + dapagliflozin 10 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06269484
NCT06269484Phase 2Completed
CompareCT.gov

A Multicentre, Randomised, Double-blind, Placebo-controlled Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Combination Compared to Zibotentan Monotherapy, Zibotentan/Dapagliflozin and Zibotentan Monotherapy Compared to Placebo in Participants With Cirrhosis

AstraZeneca·interventional·Posted Feb 21, 2024·Updated Jan 20, 2026

In Brief

A Phase 2 clinical trial evaluating Placebo (placebo matching zibotentan capsule and placebo matching dapagliflozin tablet), Zibotentan + placebo (placebo matching dapagliflozin tablet), and 1 other intervention for Liver Cirrhosis. Completed, enrolled 73 participants across 34 sites in 10 countries.

Detailed Summary

This is a Phase IIb multicentre, randomised, double-blind, parallel-group, placebo-controlled study to evaluate the safety of zibotentan/dapagliflozin in combination as compared to zibotentan monotherapy as well as zibotentan/dapagliflozin and zibotentan monotherapy as compared to placebo in patients with cirrhosis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLiver Cirrhosis
CountriesAustralia, Belgium, Czechia, Germany, Italy, Japan, Poland, Slovakia, United Kingdom, United States
Collaborators--

Timeline

Phase 2CompletedFinished
20252026
First PostedFeb 21, 2024
Enrollment StartFeb 15, 2024
Primary CompletionDec 11, 2024
TodayJul 2, 2026
Enrollment to primary: 10 monthsPosted 2.4 years ago

Interventions

Placebo (placebo matching zibotentan capsule and placebo matching dapagliflozin tablet)drug

placebo capsule (matching zibotentan capsule) placebo tablet (matching dapagliflozin tablet)

Zibotentan + placebo (placebo matching dapagliflozin tablet)drug

zibotentan capsule placebo tablet (matching dapagliflozin tablet)

Zibotentan + dapagliflozindrug

zibotentan capsule dapagliflozin 10 mg tablet