At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Analysis of Vitamin D and VDR Expression in Women With Advanced Endometriosis: A Case-Control Study in Thailand
In Brief
An observational study evaluating Vitamin D level and Vitamin D receptor for Endometriosis and 2 related conditions. Completed, enrolled 108 participants across 1 site.
Detailed Summary
The goal of this cross-sectional prospective matching study is to evaluate whether serum vitamin D levels and vitamin D receptor (VDR) expression are associated with the presence and severity of endometriosis in women of reproductive age. The main questions it aims to answer are: * Is there a difference in serum 25-hydroxyvitamin D \[25(OH)D\] levels between women with endometriosis and healthy controls? * Is there a correlation between serum vitamin D levels and VDR expression in endometriotic tissues? * Is there an association between vitamin D status and the severity of endometriosis based on the revised American Society for Reproductive Medicine (rASRM) staging? Researchers will compare participants with endometriosis to matched healthy controls (1:2 ratio). Participants will: * Provide blood samples for serum 25(OH)D measurement. * Undergo surgical tissue sampling (for the endometriosis group) to assess VDR expression using immunohistochemistry staining. * Complete structured questionnaires regarding sun exposure, lifestyle, and clinical characteristics.
Study Details
Timeline
Interventions
Vitamin D level in blood
Vitamin D receptor in endometriosis tissue