At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Prospective Single-Blinded Randomized Field-Based Trial to Evaluate the Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness
In Brief
A Phase 4 clinical trial evaluating Immediate descent from altitude., Diphenhydramine, and 1 other intervention for AMS and Acute Mountain Sickness. Completed, enrolled 30 participants across 1 site.
Detailed Summary
A field-based trial was conducted to determine if oral prochlorperazine demonstrates efficacy in the prophylactic treatment of AMS, and/or decreases the incidence of the symptoms of acute mountain sickness including headache, GI symptoms, fatigue and dizziness based on data collected in the Lake Louise AMS score.
Study Details
Timeline
Interventions
Immediate descent from altitude for severe symptoms or anyone who wished to discontinue their participation in the study.
Diphenhydramine was available to counteract any potential extrapyramidal side effects of the study drug. The use of Diphenhydramine for this purpose is well established.
Subjects in the Prochlorperazine arm were administered 10mg PO Prochlorperazine immediately prior to ascent