CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 179 enrolled
Drug / intervention
retrosigmoid approach (RSA) +5 moreprocedure
Likely dose
Not stated in record
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Search/NCT06319664
NCT06319664N/ACompleted

Clinical Outcomes and Decision-making Choice of Skull Base Approaches for Petroclival Meningiomas: a Single Center Report of 179 Cases

Xiangya Hospital of Central South University·observational·Posted Mar 20, 2024·Updated Mar 20, 2024

In Brief

An observational study evaluating retrosigmoid approach (RSA), subtemporal transtentorial transpetrosal approach (STTA), and 4 other interventions for Skull Base Meningioma. Completed, enrolled 179 participants across 1 site.

Detailed Summary

Petroclival meningioma (PCM) is a technically challenging lesion. We aimed to analyze the role of various skull base approaches and evaluate the therapeutic outcomes guided by the modified classification. We retrospectively analyzed the clinical characteristics, surgical approaches, outcomes and follow-up data from 179 cases of PCM from January 2011 to December 2020. We modified the previous classification into updated five types with two subtypes: clivus type (CV), petroclival type (PC), petroclivosphenoidal type (PC-S), sphenopetroclival type (S-PC) with two subtypes of S-PC I and S-PC II and central skull base type (CSB). Statistical analysis was performed using IBM SPSS Statistical Package 21.0. The t-test was performed to clinical data comparisons between the two groups and the ANOVA test was used to compare the difference between multiple groups. P \< 0.05 was considered statistically significant.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
CountriesChina
Collaborators--

Timeline

N/ACompletedFinished
20222023202420252026
First PostedMar 20, 2024
Enrollment StartMay 27, 2021
Primary CompletionAug 10, 2021
Study CompletionSep 10, 2021
TodayJul 2, 2026
Enrollment to primary: 2 monthsPosted 2.3 years ago

Interventions

retrosigmoid approach (RSA)procedure

The skull base approach choice was fundamentally followed by the modified classification.

subtemporal transtentorial transpetrosal approach (STTA)procedure

The skull base approach choice was fundamentally followed by the modified classification.

extended pterional transtentorial approach (EPTA)procedure

The skull base approach choice was fundamentally followed by the modified classification.

pretemporal trancavernous anterior transpetrosal approach (PTCA)procedure

The skull base approach choice was fundamentally followed by the modified classification.

presigmoid combined supra-infratentorial approach (PCA)procedure

The skull base approach choice was fundamentally followed by the modified classification.

inoperableprocedure

The skull base approach choice was fundamentally followed by the modified classification.