CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 91 enrolled
Drug / intervention
Data collection from hospital medical recordsother
Likely dose
Not stated in record
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Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06361290
NCT06361290N/ACompleted

Diaphyseal Reconstruction Techniques of Lower Limbs in Childhood Malignant Tumors - Induced Membrane Technique Versus Vascularized Fibula Grafts

Assistance Publique - Hôpitaux de Paris·observational·Posted Apr 11, 2024·Updated Sep 12, 2025

In Brief

An observational study evaluating Data collection from hospital medical records for Childhood Malignant Tumors of Lower Limbs. Completed, enrolled 91 participants across 2 sites.

Detailed Summary

Primary malignant bone tumors represent 5% of malignant tumors in children, 90% of which are osteosarcomas or Ewing sarcomas. The objective of oncological resection is local control of the disease. Excision of the entire tumor should make it possible to maintain good function of the limb, minimizing morbidity, and promoting acceptance by the patient. Biological reconstructions offer the best long-term functional results. Several possibilities are then available: the Induced Membrane technique, the Vascularized Fibula and Vascularized Fibula associated with an Allograft. Until today, no reconstruction technique in children has proven its superiority over another and no decision-making algorithm for therapeutic care has been determined based on the importance of the bone resection and the affected segment in diaphyseal tumor reconstruction surgery of the lower limb. The aim of the present research is to compare the three techniques concerning the consolidation aspect, the reoperation rates, the rates of bone complications, septic, and the functional results by the study of the medical files of approximately 90 patients operated between 1986 and 2017.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
CountriesFrance

Timeline

N/ACompletedFinished
20252026
First PostedApr 11, 2024
Enrollment StartMay 30, 2024
Primary CompletionNov 30, 2024
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 2.2 years ago

Interventions

Data collection from hospital medical recordsother

Data collection from hospital medical records of patients concerning the 5 years following the resection of the tumor.