CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 841 enrolled
Drug / intervention
RSVPreF3 OA investigational vaccine +1 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06374394
NCT06374394Phase 3Completed

A Phase 3, Open-label, Randomized, Controlled Study to Evaluate the Immune Response, Safety and Reactogenicity of RSVPreF3 OA Investigational Vaccine When Co-Administered With a COVID-19 mRNA Vaccine (Omicron XBB.1.5) in Adults Aged 50 Years and Above

GlaxoSmithKline·interventional·Posted Apr 18, 2024·Updated Dec 26, 2025

In Brief

A Phase 3 clinical trial evaluating RSVPreF3 OA investigational vaccine and COVID-19 mRNA vaccine for Respiratory Syncytial Virus Infections. Completed, enrolled 841 participants across 24 sites in 4 countries.

Detailed Summary

This study is assessing the immunogenicity, safety and reactogenicity of the RSVPreF3 OA investigational vaccine when it is co-administered with a COVID-19 messenger ribonucleic acid (mRNA) vaccine (Omicron XBB.1.5), compared to administration of the vaccines separately in adults aged 50 years and above.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBelgium, Netherlands, Spain, United States
Collaborators--

Timeline

Phase 3CompletedFinished
20252026
First PostedApr 18, 2024
Enrollment StartApr 29, 2024
Primary CompletionNov 1, 2024
Study CompletionMar 31, 2025
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 2.2 years ago

Interventions

RSVPreF3 OA investigational vaccinebiological

1 dose of RSVPreF3 OA investigational vaccine is administered intramuscularly on Day 1 to participants in the Co-ad Group and on Day 31 to participants in the Control Group.

COVID-19 mRNA vaccinebiological

1 dose of COVID-19 mRNA vaccine is administered intramuscularly on Day 1 to participants in the Co-ad and Control Groups.