CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 54 enrolled
Drug / intervention
Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF loaded with metronidazole +2 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06374784
NCT06374784N/ACompleted
CompareCT.gov

The Effect of Autogenous Demineralized Dentin Graft Combined With Injectable PRF Loaded With Metronidazole Versus Autogenous Demineralized Dentin Graft Combined With Injectable PRF Versus Autogenous Demineralized Dentin Graft Alone on Alveolar Ridge Preservation of Infected Sockets: A Randomized Controlled Clinical Trial

Cairo University·interventional·Posted Apr 19, 2024·Updated Dec 15, 2025

In Brief

A clinical study evaluating Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF loaded with metronidazole, Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF, and 1 other intervention for Alveolar Bone Loss. Completed, enrolled 54 participants across 1 site.

Detailed Summary

The aim of this trial is to compare the effect of autogenous demineralized dentin graft combined with injectable PRF loaded with metronidazole (sticky demineralized tooth releasing metronidazole) versus autogenous demineralized dentin graft combined with injectable PRF (sticky demineralized tooth) versus autogenous demineralized dentin graft (ADDG) alone on alveolar ridge preservation after extraction of non restorable, infected single-rooted teeth

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAlveolar Bone Loss
CountriesEgypt
Collaborators--

Timeline

N/ACompletedFinished
20252026
First PostedApr 19, 2024
Enrollment StartMay 20, 2024
Primary CompletionMay 2, 2025
Study CompletionJun 28, 2025
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 2.2 years ago

Interventions

Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRF loaded with metronidazoleprocedure

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid as particulate demineralized dentin graft and processed with injectable platelet rich fibrin. The injectable PRF will be mixed with 5mg/ml metronidazole first then added to the particulate demineralized dentin graft forming sticky demineralized tooth graft with slowly released metronidazole then inserted in the extraction socket and covered then suturing

Alveolar ridge preservation using autogenous demineralized dentin graft combined with injectable PRFprocedure

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid as particulate demineralized dentin graft. The injectable PRF will be added to the particulate demineralized dentin graft forming sticky demineralized tooth graft then inserted in the extraction socket and covered then suturing

Alveolar ridge preservation using autogenous demineralized dentin graft aloneprocedure

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using hydrochloric acid (HCL) acid inserted in the extraction socket as particulate demineralized dentin graft