At a glance
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Impact of Desflurane Versus Isoflurane on Early Cognitive Function of the Elderly Undergoing Lumbar Surgery: A Randomized Clinical Trial
In Brief
A clinical study evaluating Isoflurane 0.8 MAC and Desflurane 0.8MAC for Postoperative Cognitive Dysfunction. Completed, enrolled 85 participants across 1 site.
Detailed Summary
Postoperative cognitive dysfunction (POCD) is a common complication after surgery that is associated with more adverse events and death. The goal of this randomized, controlled clinical study is to learn about the impact of different inhalation anesthetics may have on the elderly in terms of POCD and diagnosis performance of long intergenic non-coding RNA(LINC01844) level in blood of older people for POCD. The main question it aims to answer is: Dose the desflurane have less influence on the elderly's cognitive function in comparison with isoflurane？Does the relative level of LINC01844 in blood help diagnose POCD of older people after surgery? Participants undergoing elective lumbar decompression and fusion will finish neuropsychological evaluations one day before and 1st, 3rd and 5th day after surgery. At the same timepoint, the relative level of LINC01844 in blood will also be tested.
Study Details
Timeline
Interventions
Patients in this group will be anesthetized using isoflurane with the depth of 0.8\~1.0MAC during the operation.
Patients in this group will be anesthetized using desflurane with the depth of 0.8\~1.0MAC during the operation.