CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 36 enrolled
Drug / intervention
Estetrol 15 mg/Drospirenone 3 mg (24/4) +1 moredrug
Likely dose
Estetrol 15 mg/Drospirenone 3 mg (24/4)from record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06396221
NCT06396221N/ACompleted

"Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition: A Single-blind, Randomized Controlled, Non-inferiority Trial

Chulalongkorn University·interventional·Posted May 2, 2024·Updated May 20, 2025

In Brief

A clinical study evaluating Estetrol 15 mg/Drospirenone 3 mg (24/4) and Ethinylestradiol (EE) 20 mcg/Gestodene 75 mcg (21/7) for Ultrasound Finding: Ovulation Inhibition, Ovarian Activities and 2 related conditions. Completed, enrolled 36 participants across 1 site.

Detailed Summary

The goal of this clinical trial is to learn if Estetrol/Drospirenone inhibit ovulation in quick-starting method. It will also learn about the safety of Estetrol/Drospirenone. The main questions it aims to answer are: 1. Does Estetrol/Drospirenone inhibit ovulation inferior to Ethinyl estradiol/Gestodene when starting on Day 7-9 of menstrual cycle? 2. What are the impacts of Estetrol/Drospirenone on ovarian activities when starting on Day 7-9 of menstrual cycle? 3. How does the cervical mucus change when starting Estetrol/Drospirenone on Day 7-9 of menstrual cycle? 4. What are the adverse effects when starting Estetrol/Drospirenone on Day 7-9 of menstrual cycle? Researchers will compare Estetrol/Drospirenone to Ethinyl estradiol/Gestodene to see if Estetrol/Drospirenone inhibit ovulation in quick-starting method.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesThailand
Collaborators--

Timeline

N/ACompletedFinished
20252026
First PostedMay 2, 2024
Enrollment StartMay 1, 2024
Primary CompletionSep 30, 2024
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 2.2 years ago

Interventions

Estetrol 15 mg/Drospirenone 3 mg (24/4)drug

Completing a pack (28 pills) of Estetrol 15 mg/Drospirenone 3 mg (24/4), starting on day 7-9 of menstrual cycle

Ethinylestradiol (EE) 20 mcg/Gestodene 75 mcg (21/7)drug

Completing a pack (28 pills) of Ethinylestradiol (EE) 20 mcg/Gestodene 75 mcg (21/7), starting on day 7-9 of menstrual cycle