CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 60 enrolled
Drug / intervention
Continuous Theta-burst Stimulation +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06400407
NCT06400407Phase 2Completed

Lesion Network Mapping Navigated Continuous Theta-burst Stimulation for Motor Recovery in Acute Ischemic Stroke:A Randomized, Double-Blind, Sham-Controlled, Phase 2 Pilot Trial

Beijing Tiantan Hospital·interventional·Posted May 6, 2024·Updated Apr 8, 2026

In Brief

A Phase 2 clinical trial evaluating Continuous Theta-burst Stimulation and Sham stimulation for Stroke, Acute Ischemic. Completed, enrolled 60 participants across 1 site.

Detailed Summary

This is a multicenter, sham-controlled, double-blind, randomized clinical trial to evaluate the efficacy and safety of lesion network mapping navigated cTBS in improving motor function in patients with acute ischemic stroke within 14 days of symptom onset.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesChina
Collaborators--

Timeline

Phase 2CompletedFinished
20252026
First PostedMay 6, 2024
Enrollment StartOct 21, 2024
Primary CompletionOct 27, 2025
Study CompletionJan 12, 2026
TodayJul 2, 2026
Enrollment to primary: 1.0 yearsPosted 2.2 years ago

Interventions

Continuous Theta-burst Stimulationdevice

Based on the map, an 8-shaped coil was used to stimulate the motor function-related targets. The stimulation intensity was RMT80%, 600 pulses, 50Hz, 40s per target, and the stimulation interval was more than 2 hours. The total course of treatment lasted 7 days.

Sham stimulationdevice

A Sham stimulation coil was used to stimulate based on the map. The sound and duration were the same as the cTBS group, ensuring no effective stimulation. The total course of treatment lasted 7 days.