CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 845 enrolled
Drug / intervention
F2G22B/DL001Z +10 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06431607
NCT06431607Phase 2Completed

A Phase 2a Randomized, Observer-blind, Dose-finding Study to Evaluate the Immunogenicity and Safety of mRNA-based Multivalent Seasonal Influenza Vaccine Candidates in Adults 18 Years of Age and Older

GlaxoSmithKline·interventional·Posted May 28, 2024·Updated Mar 10, 2026

In Brief

A Phase 2 clinical trial evaluating F2G22B/DL001Z, F2H23D/DL001Z-NH, and 9 other interventions for Influenza, Human. Completed, enrolled 845 participants across 18 sites.

Detailed Summary

The purpose of this study is to assess the safety and immune response of GlaxoSmithKlines (GSK) messenger RNA (mRNA)-based multivalent vaccine (GSK4382276A) candidate against influenza, administered in healthy younger adults (YA) and older adults (OA).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
20252026
First PostedMay 28, 2024
Enrollment StartMay 23, 2024
Primary CompletionDec 27, 2024
Study CompletionJun 4, 2025
TodayJul 2, 2026
Enrollment to primary: 7 monthsPosted 2.1 years ago

Interventions

F2G22B/DL001Zbiological

Study intervention was administered intramuscularly at Day 1.

F2H23D/DL001Z-NHbiological

Study intervention was administered intramuscularly at Day 1.

F2H23B/DL001Z-NHbiological

Study intervention was administered intramuscularly at Day 1.

F2H23H/DL001Zbiological

Study intervention was administered intramuscularly at Day 1.

FDQ23A-NH (Flu D-QIV)combination

Control Vaccine was administered intramuscularly at Day 1.

GSK5800544Abiological

Study intervention was administered intramuscularly at Day 1.

Flu D-TIVcombination

Control Vaccine was administered intramuscularly at Day 1.

F2H23A/DL001Z-NHbiological

Study intervention was administered intramuscularly at Day 1.

F2H23G/DL001Zbiological

Study intervention was administered intramuscularly at Day 1.

Fluzone HD Quadrivalentcombination

Control vaccine was administered intramuscularly at Day 1.

Fluzone HDcombination

Control vaccine was administered intramuscularly at Day 1.