CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 584 enrolled
Drug / intervention
Dobutamine +1 moredrug
Likely dose
Dobutamine 5 mcg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06462313
NCT06462313N/ACompleted
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Director, Head of Anesthesiology and Critical Care, Principal Investigator, Professor

First Affiliated Hospital of Zhejiang University·interventional·Posted Jun 17, 2024·Updated Dec 4, 2025

In Brief

A clinical study evaluating Dobutamine and Norepinephrine for Patients With Septic Shock and 2 related conditions. Completed, enrolled 584 participants across 1 site.

Detailed Summary

Septic shock is the last and most severe stage of sepsis and is defined by extremely low blood pressure, despite lots of intravenous fluids. The incidence of septic shock related cardiomyopathy was 10% to 70%. Besides, general anesthesia will inhibit the sympathetic nervous system, reduce myocardial contractility and aggravate cardiac dysfunction. No randomized controlled trials have yet explore the effects of dobutamine on clinical outcomes for patients with septic shock undergoing surgery under general anesthesia.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPatients With Septic Shock, Surgical Patients, General Anesthesia
CountriesChina
CollaboratorsNingbo No. 1 Hospital, Lishui Country People's Hospital, The Central Hospital of Lishui City, Zhejiang Provincial Tongde Hospital, Ningbo No.2 Hospital, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, The First Affiliated Hospital of Zhengzhou University, Zunyi Medical College, The Second Hospital of Hebei Medical University, Affiliated Hospital of Jiaxing University, First Affiliated Hospital of Xinjiang Medical University, The First Affiliated Hospital of Anhui Medical University, Huaibei Peolple's Hospital, Anqing Municipal Hospital, The Second Hospital University of South China, The First Affiliated Hospital of University of South China, Wenzhou people's hospital，zhejiang province,China, People's Hospital of Xinjiang Uygur Autonomous Region, The First Clinical College of Harbin University, The First Affilated Hospital of the Medical College, Shihezi University, Weifang People's Hospital, Tianjin Medical University General Hospital, Central Hospital of Heng Yang, First Affiliated Hospital of Shenzhen University, Henan Provincial People's Hospital, Southwest Hospital, China, The First People's Hospital of Zunyi, Affiliated Hospital of Guangdong Medical University, Union hospital of Fujian Medical University, Zhejiang Provincial People's Hospital, Red Cross Hospital, Hangzhou, China, Weihai Municipal Hospital, The First Affiliated Hospital of Soochow University, Zhejiang Cancer Hospital, Renmin Hospital of Wuhan University, Wuhan Third Hospital, Tongji Hospital, Zhujiang Hospital, Fuyang Hospital of Anhui Medical University, The Hospital of Suixi County, Fujian Provincial Hospital, Guizhou Provincial People's Hospital

Timeline

N/ACompletedFinished
20252026
First PostedJun 17, 2024
Enrollment StartJun 18, 2024
Primary CompletionNov 15, 2025
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 2.0 years ago

Interventions

Dobutaminedrug

Patients with septic shock in Dobutamine group will be initiated on Dobutamine at 5 mcg/kg/min when electrocardiogram, invasive blood pressure, and oxygen saturation were monitored.

Norepinephrinedrug

Norepinephrine was titrated to maintain a mean arterial pressure at 65mmHg or more in both groups.