At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Accelerated Vascular Aging in Midlife as a Mechanism Linking Daily Stress to Cognitive Decline
In Brief
A clinical study evaluating MitoTempol and Lactated Ringer's (control) for Middle-aged Adults and Major Depressive Disorder. Completed, enrolled 17 participants across 1 site.
Detailed Summary
The goal of this pilot clinical trial is to begin to understand how day-to-day stress affects cardiovascular health and brain function in middle-aged adults. The main question aims to answer is whether the link between daily stress and vascular dysfunction is a potential mechanism of increased risk for future cognitive decline. Participants will complete a 15-day testing cycle. During this cycle, participants will complete daily assessments of stress using an online survey tool for 14-consecutive days. On the last day of each cycle, vascular function will be assessed during a laboratory visit.
Study Details
Timeline
Interventions
One intradermal microdialysis probes will be perfused with MitoTempol (0.5 mM) during a standard local skin heating protocol.
One intradermal microdialysis probes will be perfused with lactated Ringer's (control) during a standard local skin heating protocol.