At a glance
ClinicalIndex Comparison Record- ✓Pathologically-proven squamous cell carcinoma of oropharynx, larynx, or hypopharynx
- ✓Measurable disease at primary site and/or nodal stations
- ✓Clinical stage I-IVB (AJCC 7th edition); stages I-II glottic excluded
- ✓Age ≥18 years
- ✕Distant metastasis
- ✕Unable to undergo contrast-enhanced CT or PET-CT
- ✕Stage I-II glottic carcinoma
- ✕Gross total excision of primary and nodal disease
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
INVERT - Prospective Phase II Randomized Trial of Involved Nodal Versus Elective Neck RadioTherapy
In Brief
A Phase 2 clinical trial evaluating ENI using IMRT with or without chemotherapy, INRT, and 1 other intervention for Head and Neck Cancer. Currently recruiting, targeting 80 participants across 1 site.
Detailed Summary
To determine the risk of solitary elective volume recurrence following involved nodal radiotherapy (INRT) versus elective nodal irradiation (ENI)
Study Details
Timeline
Interventions
This study is a phase II single-blinded randomized trial comparing standard ENI with involved nodal radiotherapy. INRT using intensity modulated radiation therapy (IMRT) with or without chemotherapy (if given, either cisplatin, cetuximab, or carboplatin- paclitaxel)
INRT using intensity modulated radiation therapy (IMRT) with or without chemotherapy (if given, either cisplatin, cetuximab, or carboplatin- paclitaxel)
ENI using IMRT with or without chemotherapy