At a glance
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Vitamin E Supplementation for Children With Transfusion Dependent Beta Thalassemia on Different Iron Chelators
In Brief
A clinical study evaluating vitamin E and PLACEBO for Beta-Thalassemia. Completed, enrolled 180 participants across 1 site.
Detailed Summary
repeated transfusions are the mainstay of disease management in most patients with transfusion dependent beta thalassemia.iron overload predispose to oxidative stress and tissue injury. oxidative stress play important role in pathogenesis of anemia in beta thalassemia. vitamin E is often depleted in thalassemia patients.
Study Details
Timeline
Interventions
Vitamin E will be taken for 12 months for beta thalassemia patiens on regular packed red blood cell transfusion and chelators(desferoxamine,deferiprone and deferasirox )
placebo will be taken for 12 months for beta thalassemia patiens on regular packed red blood cell transfusion and chelators(desferoxamine,deferiprone and deferasirox )