CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 10 enrolled
Drug / intervention
Not specified
Likely dose
Not stated in record
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Search/NCT06517524
NCT06517524N/ACompleted

Effects of Low-pressure Pneumoperitoneum Associated With Deep Pipecuronium-induced Neuromuscular Blockade on Hemodynamic Parameters for High Cardiovascular Risk Patient Undergoing General Anesthesia

Tamas Vegh, MD·observational·Posted Jul 24, 2024·Updated Jul 24, 2024

In Brief

An observational study for Residual Neuromuscular Block and 2 related conditions. Completed, enrolled 10 participants across 1 site.

Detailed Summary

Deep neuromuscular block (DNMB) during laparoscopy induces less haemodynamic stress by facilitating low-pressure pneumoperitoneum. the investigators tested the feasibility of pipecuronium-induced deep (post-tetanic count ≥1, train-of-four count = 0) NMB to allow low intraabdominal pressures and maintain cardiovascular stability in patients with low cardiac ejection fraction.MethodsTen adult, NYHA 3-4 surgical patients requiring non-elective abdominal surgery, were included. Pipecuronium bromide (PIPE) 0.09 mg/kg was used for muscle relaxation and maintenance of DNMB. Top-up doses of PIPE were administered when the post-tetanic count was 4-8. Intraabdominal pressures (IAP) were kept below 10 mmHg. Mean arterial pressure (MAP) was measured intra-arterially. Outcome measures used: weight in kilograms, height in meters, need for circulatory suppert (yes/no), success of maintenance (yes/no). Surgical field view was rated on a 5-point scale (1= extremely poor, 5 = optimal)

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
CountriesHungary
Collaborators--

Timeline

N/ACompletedFinished
2023202420252026
First PostedJul 24, 2024
Enrollment StartJan 8, 2023
Primary CompletionJun 5, 2024
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 1.9 years ago