CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 406 enrolled
Drug / intervention
Placebo (placebo matching AZD5004 film-coated tablet) +2 moredrug
Likely dose
Semaglutide 14 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06579105
NCT06579105Phase 2Completed

A Phase IIb, Randomized, Double-blind, Placebo-controlled and Open-label Active Comparator Study to Evaluate the Efficacy, Safety, and Tolerability of AZD5004 in Adults With Type 2 Diabetes Mellitus.

AstraZeneca·interventional·Posted Aug 30, 2024·Updated Jan 13, 2026

In Brief

A Phase 2 clinical trial evaluating Placebo (placebo matching AZD5004 film-coated tablet), AZD5004, and 1 other intervention for Diabetes Mellitus, Type 2. Completed, enrolled 406 participants across 97 sites in 9 countries.

Detailed Summary

This is a Phase IIb, randomised, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy, safety and tolerability of AZD5004 in adults with type 2 diabetes mellitus, compared to placebo and active comparator.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada, Germany, Hungary, Japan, Poland, Slovakia, Spain, United Kingdom, United States
Collaborators--

Timeline

Phase 2CompletedFinished
20252026
First PostedAug 30, 2024
Enrollment StartOct 8, 2024
Primary CompletionDec 19, 2025
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 1.8 years ago

Interventions

Placebo (placebo matching AZD5004 film-coated tablet)drug

Placebo film-coated tablet (matching AZD5004)

AZD5004drug

AZD5004 film-coated tablet, once daily during 26 weeks

Semaglutidedrug

3-14 mg tablets of Semaglutide