CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 120 enrolled
Drug / intervention
Aesculus hippocastanum, and associationsdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06579482
NCT06579482Phase 4Completed

Clinical Study of Non-inferiority Between Aesculus Hippocastanum 50mg, Polygonum Acre 10mg, Smilax Pepyracea 40mg, Rutin 20mg Versus Diosmin 450mg and Hesperidin 50mg Tablets in Chronic Venous Insufficiency After 3 Months of Therapy

Fundação Educacional Serra dos Órgãos·interventional·Posted Aug 30, 2024·Updated Jan 7, 2026

In Brief

A Phase 4 clinical trial evaluating Aesculus hippocastanum, and associations for Chronic Venous Insufficiency. Completed, enrolled 120 participants across 1 site.

Detailed Summary

To demonstrate the clinical non-inferiority of efficacy between Aesculus hippocastanum, Polygonum acre, Smilax Pepyracea, Rutin and Diosmin 450mg and Hesperidin 50mg tablets in the improvement of lower limb symptoms assessed by means of a 100mm visual scale (VAS) over 3 months among adult patients presenting with chronic venous insufficiency of the lower limbs.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBrazil
Collaborators--

Timeline

Phase 4CompletedFinished
20252026
First PostedAug 30, 2024
Enrollment StartNov 6, 2024
Primary CompletionMay 5, 2025
Study CompletionJun 11, 2025
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 1.8 years ago

Interventions

Aesculus hippocastanum, and associationsdrug

combination product