CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 281 enrolled / 281 target
Drug / intervention
Ixekizumab +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06588283
NCT06588283Phase 3CompletedMonitor (13.4/mo)Completion was 5mo ago

Efficacy and Safety of Ixekizumab or Ixekizumab Concomitantly Administered With Tirzepatide in Adult Participants With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight: A Phase 3b, Randomized, Multicenter, Open-Label Study (TOGETHER-PsO)

Eli Lilly and Company·interventional·Posted Sep 19, 2024·Updated Jun 17, 2026

In Brief

A Phase 3 clinical trial evaluating Ixekizumab and Tirzepatide for Psoriasis and Obesity. Completed, enrolled 281 participants across 72 sites in 2 countries.

Signals

Enrolling slower than its timeline implies

Detailed Summary

The main purpose of this study is to demonstrate that when participants with moderate to severe plaque psoriasis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide concomitantly administered, participants see improvement in their psoriasis and achieve weight reduction compared to when receiving ixekizumab. Participation in this study includes up to 12 visits and could last up to 61 weeks including screening, open label treatment period, and post-treatment follow-up period.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPsoriasis, Obesity
CountriesPuerto Rico, United States
Collaborators--

Timeline

Phase 3CompletedFinished
20252026
First PostedSep 19, 2024
Enrollment StartSep 30, 2024
Primary CompletionJan 8, 2026
Study CompletionJun 1, 2026
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 1.8 years ago

Arms & Interventions

Ixekizumabexperimental

Ixekizumab administered subcutaneous (SC).

Drug: Ixekizumab
Ixekizumab and Tirzepatideexperimental

Ixekizumab concomitantly administered with tirzepatide SC.

Drug: IxekizumabDrug: Tirzepatide

Interventions

Ixekizumabdrug

Administered SC

Tirzepatidedrug

Administered SC.