CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 150 enrolled
Drug / intervention
The new HFNC weaning protocolbehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06621641
NCT06621641N/ACompleted

Outcomes of a Nurse-led High-flow Nasal Cannula Weaning Protocol in Pediatric Critical Bronchiolitis Patients

Dr. Behcet Uz Children's Hospital·interventional·Posted Oct 1, 2024·Updated Nov 25, 2025

In Brief

A clinical study evaluating The new HFNC weaning protocol for Bronchiolitis and 2 related conditions. Completed, enrolled 150 participants across 6 sites.

Detailed Summary

Bronchiolitis is a leading cause of pediatric hospital admissions. Despite its limited clinical benefits, the use of HFNC in children with bronchiolitis is increasing. Previous studies using quality improvement (QI) methodologies have successfully reduced HFNC usage through weaning protocols and trials of standard oxygen therapy. This study involves implementing an HFNC initiation and weaning protocol at Aydın Maternity and Children's Hospital, involving infants aged 1-24 months admitted with bronchiolitis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesTurkey (Türkiye)
CollaboratorsHamilton Medical AG

Timeline

N/ACompletedFinished
20252026
First PostedOct 1, 2024
Enrollment StartOct 1, 2024
Primary CompletionMay 30, 2025
Study CompletionJun 30, 2025
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 1.8 years ago

Interventions

The new HFNC weaning protocolbehavioral

Patients will be randomly assigned to two groups: one following the new HFNC weaning protocol and another using the standard care protocol. The new protocol includes stepwise flow reduction based on the patient's clinical stability and uses the Respiratory Assessment Scale (RAS) to monitor weaning progress. The protocol emphasizes a multidisciplinary approach involving pediatricians, nurses, and respiratory therapists, with consistent training and application of weaning criteria