CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 26,248 enrolled
Drug / intervention
Pre-visit patient text messaging +3 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06626321
NCT06626321N/ACompleted

BE IMMUNE: Behavioral Economics to IMprove and Motivate Vaccination Using Nudges Through the EHR, A Replication Trial

University of Pennsylvania·interventional·Posted Oct 3, 2024·Updated Mar 30, 2026

In Brief

A clinical study evaluating Pre-visit patient text messaging, Default pended order, and 2 other interventions for Behavior, Health and 2 related conditions. Completed, enrolled 26,248 participants across 1 site.

Detailed Summary

This study will be a 6-month, cluster randomized, pragmatic replication trial to evaluate the effectiveness of personalized nudges to clinicians and patients, relative to a control, to increase flu vaccination rates among older adults in accordance with CDC guidelines. This will include clinician and patient level nudge interventions, with additional, intensified nudge interventions for patients identified as high risk for not receiving a flu vaccine. Among the intervention clinics, patients will receive pre-visit text message reminders about the flu vaccine, and clinicians will receive a default pended order in the visit encounter in the EHR, along with monthly peer comparison feedback about their flu vaccine completion rate. Patients identified as high risk for noncompletion will be individually randomized to receive an additional bidirectional text message nudge or the standard text messaging

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
20252026
First PostedOct 3, 2024
Enrollment StartOct 21, 2024
Primary CompletionFeb 28, 2025
Study CompletionMay 28, 2025
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 1.7 years ago

Interventions

Pre-visit patient text messagingbehavioral

Patients will be sent text message reminders 3 days and 24 hours prior to their scheduled primary care visit. The messages will inform the patient that a flu shot has been reserved for them at their upcoming visit and encourage the patient to ask their provider about receiving the vaccine.

Default pended orderbehavioral

A default pended order for the flu vaccine will be pended to the patients upcoming primary care encounter and will be visible to the provider during the visit encounter. Clinical staff will have the option of signing the order or dismissing it if they deem it inappropriate for a given patient.

Monthly peer comparison feedbackbehavioral

Each month, clinicians will be sent an email containing what percent of their eligible patients received the flu vaccine and how that compares to other peer clinicians in the intervention

High risk bidirectional pre-visit text messagingbehavioral

High risk patients randomized to receive the high risk intensification nudge will receive a bidirectional text messaging component prior to their visit. This intervention will query the patient about common questions or concerns about receiving the flu vaccine. If the patient responds, it will provide additional educational materials based on the patient's specific concern(s).