CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 7,505 enrolled
Drug / intervention
Behavioral Activation (Action Brings Change Project 10-Minute Version) +12 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06856668
NCT06856668N/ACompleted

A Megastudy of Single-Session Interventions to Challenge Depression in American Adults

Northwestern University·interventional·Posted Mar 4, 2025·Updated Jun 27, 2025

In Brief

A clinical study evaluating Behavioral Activation (Action Brings Change Project 10-Minute Version), Mindful Acceptance, and 11 other interventions for Depression - Major Depressive Disorder. Completed, enrolled 7,505 participants across 1 site.

Detailed Summary

This project aims to learn if new kinds of digital single-session interventions (SSIs) for depression could be effective for American adults. Many existing SSIs are delivered in a simple text-based format. However, it might be that different kinds of SSIs (in terms of both content and style) also have potential for scalable impact. Specifically, this study will investigate the effectiveness of 11 innovative SSIs by comparing them to a passive control and to an existing SSI with established efficacy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
2026
First PostedMar 4, 2025
Enrollment StartMar 11, 2025
Primary CompletionJun 24, 2025
TodayJul 2, 2026
Enrollment to primary: 3 monthsPosted 1.3 years ago

Interventions

Behavioral Activation (Action Brings Change Project 10-Minute Version)behavioral

A behavioral activation SSI where users learn about negative thought spirals, give advice to an imagined peer, then create an "action plan" of helpful activities to do in the near future. This is a shorter version of the original 15-minute Action Brings Change SSI.

Mindful Acceptancebehavioral

A clinical psychologist explains a few ways to use mindful acceptance to deal with difficult thoughts and feelings.

Moral Elevationbehavioral

Users learn about moral elevation, then watch a touching video where a man does good deeds for people in his community (originally a Thai life insurance advertisement). Finally, they plan a positive action they can take to help others in their own life.

Mindful Attention Skillsbehavioral

A series of videos teach mindfulness skills: how to release thoughts and re-evaluate negative interpretations.

5 Habits to Beat Depressionbehavioral

A clinical psychologist and science communicator describes his top 5 one-minute habits to beat depression.

Interactive Cognitive Reappraisalbehavioral

An interactive SSI where participants learn how to reframe negative thoughts

Expressive Writing (AI-supported)behavioral

Participants describe a negative thought they struggle with and an LLM helps them to consider a story in which a peer overcomes that thought.

Inner Child Healing Walkbehavioral

An interactive journey to reconnect and heal one's inner child through breathing exercises, positive affirmations, and supportive animal companions.

Savoring Strategiesbehavioral

An SSI introducing savoring strategies to improve mood.

Personalized Intervention Recommenderbehavioral

Identifies the kinds of depression one struggles most with and offers a personalized recommendation for future depression support options

Dialectical Behavioral Therapy Skillsbehavioral

Presents videos from dialectical behavioral therapy on various ways to control negative emotions.

All about Troutbehavioral

An 8-10 minute educational program with information and interactive exercises about trout fish. Intended to capture one's attention and require some effort, while minimizing influence on depressive symptoms.

Reframing Negative Thoughtsbehavioral

An audio-only program in which users are guided to reflect on how they might challenge negative automatic thoughts and beliefs they struggle with.