At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery
In Brief
A Phase 1 clinical trial evaluating Midazolam Hydrochloride, Fentanyl, and 3 other interventions for Anesthesia and Tooth Extraction. Completed, enrolled 73 participants across 1 site.
Detailed Summary
The purpose of this pilot study was to compare two commonly employed intravenous drug combinations; I) nitrous oxide, midazolam, fentanyl, and ketamine and II) the same combination with substitution of propofol for ketamine, for use during wisdom teeth extraction. Measures of recovery, amnesia testing 20 minutes after induction and after completion of recovery tests, patient satisfaction, and surgeon satisfaction will be evaluated. The data from this pilot study will be used to obtain preliminary estimates of effect sizes and to select primary and secondary endpoints for the design of a larger scale and more definitive trial of the two anesthetic approaches.
Study Details
Timeline
Interventions
Short-acting sedative. Benzodiazepine. Gamma-aminobutyric acid (GABA) inhibitor
Synthetic opioid drug used as an analgesic.
General Anesthetic. N-methyl-D-aspartate (NMDA) receptor agonist
General Anesthetic. GABA receptor modulator and calcium channel blocker
Modulates a wide range of ligand-gated ion channels and inhibits NMDA receptor-mediated currents