CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 156 enrolled
Drug / intervention
Mi-Helperdevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06874361
NCT06874361N/ACompleted

A Prospective, Double-blind, Sham-controlled, Randomized Clinical Trial to Assess the Safety and Efficacy of the Mi-Helper Device for Acute Treatment of Migraine in an At Home Setting.

Mi-Helper, Inc.·interventional·Posted Mar 13, 2025·Updated Feb 10, 2026

In Brief

A clinical study evaluating Mi-Helper for Migraine With or Without Aura and 2 related conditions. Completed, enrolled 156 participants across 1 site.

Detailed Summary

This is a prospective, double-blind, sham-controlled, randomized, decentralized trial. This study aims to assess the safety and efficacy of the Mi-Helper transnasal cooling device for acute treatment of migraine in an at home setting. Adults aged 18 years to 70 years old with a diagnosis of migraine (with or without aura) for at least one year will be recruited for this study.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2026
First PostedMar 13, 2025
Enrollment StartMar 24, 2025
Primary CompletionOct 29, 2025
Study CompletionDec 15, 2025
TodayJul 2, 2026
Enrollment to primary: 7 monthsPosted 1.3 years ago

Interventions

Mi-Helperdevice

The Mi-Helper device is a non-invasive, drug-free, novel therapy that uses a patented process of dry air flow across the nasal turbinates to induce a phase change (evaporation) that extracts energy (thermodynamics) causing local cooling which modulates nerves associated with pain and other symptoms of migraine. The device delivers a controlled pressure and flow of dry room temperature air along with a nebulized saline mist for added comfort and evaporative efficiency.