At a glance
ClinicalIndex Comparison Record- ✓Female participants age 40 or older
- ✓Able to provide informed consent
- ✓pTis-2 pN0 cM0 breast cancer with tumor size <3 cm
- ✓Able to complete participant reported outcomes independently or with assistance
- ✕History of non-breast malignancies except adequately treated non-melanoma skin cancers or in situ cancers treated by local excision or other cancers curatively treated with ≥5 years disease-free
- ✕Uncontrolled concurrent malignant cancer
- ✕Seroma not visible
- ✕Ipsilateral implanted cardiac device
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Phase II Single vs Hypofractionated Irradiation For Timely Access to Partial Breast Radiotherapy: SHIFT-PB
In Brief
A clinical study evaluating Multiple Fraction PBI and Single Fraction PBI for Breast Cancer Early Stage Breast Cancer (Stage 1-3). Currently recruiting, targeting 60 participants across 1 site.
Detailed Summary
Partial Breast Irradiation (PBI) is a targeted radiation approach commonly administered post-lumpectomy, specifically targeting the tumour bed. This targeted therapy reduces the exposure to other nearby tissues such as lungs, heart, and chest wall. However, traditional PBI treatment involves lengthy multiple fraction courses which presents a burden to patients from rural and remote communities, who must travel long distances to receive high quality cancer care. The purpose of this study is to compare single fraction (SF) PBI vs. multiple fraction (MF) PBI.
Study Details
Timeline
Arms & Interventions
For participants randomized to Arm 1, PBI will be delivered with a dose of 26 Gy in 5 daily fractions.
For participants randomized to Arm 2, PBI will be delivered in a single fraction with a dose of 13 Gy.
Interventions
Participants randomized to Arm 1 will receive PBI with a dose of 26 Gy in 5 daily fractions.
Participants randomized to Arm 2 will receive PBI in a single fraction with a dose of 13 Gy.