CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 3 enrolled
Drug / intervention
Olipudase alfadrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT06949358
NCT06949358Phase 2Completed

A Long-Term Follow-up Study to Evaluate Safety and Tolerability of Olipudase Alfa in Patients Who Completed the DFI12712 or the LTS13632 Study in France

Sanofi·interventional·Posted Apr 29, 2025·Updated Apr 13, 2026

In Brief

A Phase 2 clinical trial evaluating Olipudase alfa for Acid Sphingomyelinase Deficiency. Completed, enrolled 3 participants across 2 sites.

Detailed Summary

This was an open-label study to evaluate safety and tolerability and provide enzyme replacement therapy (ERT) with olipudase alfa to patients with acid sphingomyelinase deficiency (ASMD) who completed the DFI12712 or the LTS13632 Study in France until olipudase alfa reimbursement was granted in France. Study and treatment duration: The period between the participant's completion of Study DFI12712 or LTS13632 and olipudase alfa reimbursement was available in France. In case reimbursement was not obtained, this study ended 5 years after starting. Visit frequency: every 2 weeks.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesFrance
Collaborators--

Timeline

Phase 2CompletedFinished
20222023202420252026
First PostedApr 29, 2025
Enrollment StartNov 18, 2021
Primary CompletionApr 8, 2025
TodayJul 2, 2026
Enrollment to primary: 3.4 yearsPosted 1.2 years ago

Interventions

Olipudase alfadrug

Pharmaceutical form:Powder for concentrate for solution for infusion-Route of administration:intravenous infusion