At a glance
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Direct Carotid Sinus Nerve Stimulation in Anesthetized Human Subjects
In Brief
A clinical study evaluating CSN electrode was implanted around tissue including CSN branches for HTN-Hypertension and Blood Pressure Management. Completed, enrolled 18 participants across 1 site.
Detailed Summary
Uncontrolled hypertension (HTN) is growing in incidence globally creating a critical need for alternative therapeutic strategies. Directly stimulating the carotid sinus nerve (CSN) is known to potentially reduce blood pressure (BP) but its clinical efficacy has not been consistently demonstrated with existing electrode technologies in humans. We investigated the effect of acute direct CSN stimulation on BP and HR in anesthetized humans using an application-specific multi-contact electrode.
Study Details
Timeline
Interventions
Using a novel surgical approach, a custom electrode was implanted around tissue including CSN branches in anesthetized adults. Following functional mapping, presumed baroafferent fibers were identified via response and stimulated. Outcome measures included change in systolic BP (SBP), diastolic BP (DBP), and heart rate (HR) during and after stimulation using multi-level modeling. Secondarily, dose dependency was examined.