At a glance
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The Effect of Laparoscopic Sleeve Gastrectomy on Blood Phoenixin-14 Levels: A Prospective Cohort Study
In Brief
An observational study evaluating Preoperative blood sampling for determining Phoenixin 14 levels and Postoperative blood sampling for determining Phoenixin 14 levels for Obesity, Morbid and Obesity and Overweight. Completed, enrolled 36 participants across 1 site.
Detailed Summary
Obesity is a major global health concern with a rising prevalence and numerous associated comorbidities. For the treatment of severe obesity, bariatric surgery stands as the most effective procedure. Bariatric and metabolic surgical procedures are applied even in the absence of comorbidities, particularly in patients with Type-III obesity and above. Currently, the most commonly performed bariatric metabolic surgical procedures are Laparoscopic Sleeve Gastrectomy (LSG) and Roux-en-Y gastric bypass. Animal studies have shown that phoenixin (PNX) in the paraventricular, arcuate, and solitary tract nuclei contributes to regulating food intake, and its intracerebral administration in rats increased food intake. The aim of this study is to investigate whether PNX-14 levels change before and after LSG in patients undergoing the procedure for severe obesity, given the potential association of PNX-14 with obesity and insulin resistance through its influence on the appetite center in metabolism.
Study Details
Timeline
Interventions
In addition to routine blood draws for pre-operative preparations, 5 ml of blood will be collected.
In addition to routine blood draws for postoperative controls, 5 ml of blood will be collected.