At a glance
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The Effect of Intermittent Feeding on Circadian Rhythm in Critical Illness
In Brief
A clinical study evaluating Intermittent feeding and Continuous feeding for Critical Illness. Completed, enrolled 24 participants across 1 site.
Detailed Summary
The goal of this clinical trial is to determine whether intermittent enteral feeding positively influences circadian rhythms in critically ill patients in intensive care units (ICUs). The main research questions are: 1. Does intermittent feeding improve circadian rhythms in ICU patients? 2. How does intermittent feeding affect metabolic markers and recovery outcomes? Researchers will compare intermittent feeding to continuous feeding, the current standard method, to assess its impact on circadian stability and patient health. Participants will: 1. Receive intermittent enteral feeding or continuous enteral feeding for at least 10 days 2. Undergo blood sample collection at three time points daily (morning, afternoon, midnight) to analyze circadian gene expression and metabolic markers 3. Have their clinical condition, nutrition status, and recovery progress monitored throughout the study
Study Details
Timeline
Interventions
Feeding Frequency: Enteral nutrition will be provided every 4 to 6 hours via nasogastric tube. Feeding Volume: Each session will deliver 240 to 720 mL of enteral formula. Feeding Duration: Each feeding session will last approximately 20 to 60 minutes.
Feeding Frequency: Enteral nutrition will be administered continuously for 20 hours per day via nasogastric tube. Feeding Volume: The total daily volume will be divided evenly over the 20-hour infusion period, based on individual nutritional requirements. Feeding Duration: Each 24-hour cycle includes 20 hours of continuous feeding followed by a 4-hour rest period.