CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 131,005 enrolled
Drug / intervention
nirmatrelvir-ritonavirdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07072793
NCT07072793N/ACompleted

Work Productivity Losses in the United States Among High-risk Patients With COVID-19 During Acute and Longer-term Follow-up in an Omicron Predominant Period (PULSE-US)

Pfizer·observational·Posted Jul 18, 2025·Updated Feb 9, 2026

In Brief

An observational study evaluating nirmatrelvir-ritonavir for COVID-19 (Coronavirus Disease 2019). Completed, enrolled 131,005 participants across 1 site.

Detailed Summary

The purpose of this study is to understand how COVID-19 affects people's ability to work and to calculate the costs associated with loss of work. The study compares two groups of participants who are confirmed to have mild-to moderated COVID-19 and who have high chances of the disease becoming severe. The two groups are: People who took the antiviral medication nirmatrelvir-ritonavir (also called Paxlovid) People who were eligible to receive antiviral medication but did not receive any. The participants will be selected from various health databases in the US between June 2021 and December 2022. The main goals are: To look at the characteristics of both groups of participants with COVID-19. To measure how much work these participants missed, including days off and sick leave, and the costs associated with this work loss. To compare work loss and costs between the two groups of participants, considering differences in their clinical and demographic characteristics. The study will evaluate at least 30 days of data from participants after they are confirmed to have COVID-19

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20252026
First PostedJul 18, 2025
Enrollment StartOct 31, 2024
Primary CompletionNov 15, 2024
TodayJul 2, 2026
Enrollment to primary: 14 daysPosted 11 months ago

Interventions

nirmatrelvir-ritonavirdrug

Participants with confirmed diagnosis of Covid-19 and with mild to moderate symptoms at high-risk for progressing to severe disease