CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 20 enrolled
Drug / intervention
Sham Laser irradiation +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07169032
NCT07169032Early Ph 1Completed

The Effect of Er,Cr:YSGG Laser-assisted Topical Anesthetic on Oral Mucosal Anesthesia

Li Zhen Zhong·interventional·Posted Sep 11, 2025·Updated Dec 4, 2025

In Brief

A Early Phase 1 clinical trial evaluating Er,Cr:YSGG laser irradiation, Sham Laser irradiation, and 2 other interventions for Anesthesia. Completed, enrolled 20 participants across 1 site.

Detailed Summary

This study tests whether using an Er,Cr:YSGG laser before applying numbing gel (lidocaine) can help reduce pain during dental procedures compared to traditional methods. Investigators want to know: Does the laser make the numbing gel work better and longer? Does it lower pain and keep patients calmer (measured by heart rate)? Investigators enrolled 20 adults (10 men, 10 women) and assigned them to three groups: Laser + Numbing Gel: Laser was used on the gums before applying lidocaine. Sham Laser + Numbing Gel: A fake laser was used with lidocaine. Sham Laser + Vaseline: A fake laser was used with Vaseline (no numbing effect). Participants reported pain levels on a scale (0=no pain, 10=worst pain) when a tiny needle touched their gums. Investigators also checked their heart rate.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAnesthesia
CountriesChina
Collaborators--

Timeline

Early Ph 1CompletedFinished
202420252026
First PostedSep 11, 2025
Enrollment StartJan 1, 2024
Primary CompletionFeb 20, 2024
Study CompletionFeb 21, 2024
TodayJul 2, 2026
Enrollment to primary: 2 monthsPosted 10 months ago

Interventions

Er,Cr:YSGG laser irradiationdevice

irradiation with a 2780 nm, 1.0 W Er,Cr:YSGG laser for 1 minute

Sham Laser irradiationdrug

sham laser irradiation for 1 minute

Lidocainedrug

2% lidocaine gel

Vaselinedrug

Vaseline