At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Sigh in Pressure Support Ventilation to Detect Respiratory System Compliance and Lung Recruitability
In Brief
A clinical study evaluating PSV + sigh (Clinical PEEP and Clinical PEEP + 3 cmH₂O) for Mechanical Ventilation. Completed, enrolled 110 participants across 2 sites.
Detailed Summary
The goal of this physiological study is to determine whether ventilator-delivered sigh breaths during pressure support ventilation (PSV) provide a reliable bedside index of lung recruitability and can guide PEEP optimization.The main questions it aims to answer are: * Does respiratory system compliance measured at the end of a sigh (Crs\_sigh) differ from compliance obtained with an inspiratory hold during an assisted breath (Crs\_assisted), and can the Crs\_sigh/Crs\_assisted ratio indicate recruitability? * Does adjusting PEEP based on the sigh-derived recruitability index improve respiratory mechanics and gas exchange compared with usual clinical PEEP settings?
Study Details
Timeline
Interventions
Each patient undergoes two sequential 15-minute steps: 1) pressure support ventilation at the clinical PEEP and 2) the same settings with PEEP increased by 3 cmH₂O. A ventilator-delivered sigh is programmed as one sustained inflation at 30 cmH₂O for 3 seconds every minute. All other ventilator parameters (trigger sensitivity, pressure support level, mandatory breath timing) remain unchanged. At the end of each step, inspiratory and expiratory holds are performed to collect respiratory mechanics and arterial blood gases; compliance during the sigh is calculated once flow is zero and airway pressure is stable.