CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 100 enrolled
Drug / intervention
Cryotherapy +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07198022
NCT07198022Phase 4Completed

Comparative Evaluation of Application of Topical Anesthetic Gel, Solution and Cryotherapy

Ondokuz Mayıs University·interventional·Posted Sep 30, 2025·Updated Feb 9, 2026

In Brief

A Phase 4 clinical trial evaluating Cryotherapy, topical anesthetic, and 1 other intervention for Healthy and 3 related conditions. Completed, enrolled 100 participants across 1 site.

Detailed Summary

In this study, the investigators aimed to compare the effects of topical anesthetic materials and cold application on pain perception. The main questions it aims to answer are: * Is cold application is effective as a topical anesthetic replacement? * Is there a difference on pain perception between cold and room temperature topical anesthetic? The treatment contains of participants selected from a group of patients who requires dental treatment. The mission of the participants is to answer the questionnaires correctly and cooperate the treatment. Participants will be divided into 4 groups containing 25 child per group: * First group: topical anesthetic spray solution. * Second group: topical anesthetic gel * Third group: Cryotherapy as distilled water * Fourth group: Cryotherapy as topical anesthetic spray solution. All participants will answer questionnaire of pain, anxiety and taste. The oxygen saturation and pulses will be measured with a pulse-oxymeter device to be recorded.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesTurkey (Türkiye)
Collaborators--

Timeline

Phase 4CompletedFinished
2026
First PostedSep 30, 2025
Enrollment StartSep 1, 2025
Primary CompletionJan 15, 2026
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 9 months ago

Interventions

Cryotherapydrug

Using crytotherapy as topical anesthetic

topical anestheticdrug

Comparing the two versions (the room temperature and + 4°C) of the gold standard of local anesthetics, the solution, which contains lidocaine.

Topical anesthetic geldrug

Tolerable taste, containing benzocaine at gel formula.