At a glance
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NCT07213726N/AActiveUpdate OverdueUpdated 6mo ago · Completion was 31mo agoQuantification of Peripheral Hematopoietic Progenitor Cell Circulation Following Repeated Acute, Vascular Restriction Resistance Exercise Using the Delfi Tourniquet System
In Brief
A clinical study evaluating Delfi Personalized Tourniquet System for Blood Flow Restriction (BFR) Training Effects. Active but no longer recruiting, targeting 15 participants across 1 site.
Signals
Detailed Summary
The purpose of this observational study is to examine how slowing down blood flow to the legs- a practice called blood flow restriction (BFR)- during exercise by applying compression to the legs affects the way stem cells are released into the blood stream. This will be determined by drawing 6 cubic centimeters (ccs) of blood immediately post-exercise after the Delfi Personalized Tourniquet System (PTS) has been removed. 6 ccs of blood will also be taken prior to exercise and at the 20-, 40-, and 60-minute marks after exercise. The main question of this study is: • Will the levels of stem cells extracted before and after exercise be the same if blood flow is restricted during exercise? In this study, participants will undergo the following: * 6 ccs of blood extracted from the forearm prior to exercise to establish a baseline * 3 exercises- seated leg extension, semi-reclined leg press, and seated hamstring curl- consisting of 4 sets of 30-15-15-15 repetitions per exercise; resistance will be set to 30% of one-rep maximum (1-RM) * Additional 6 cc blood draws will be performed immediately post-exercise and after 20, 40, and 60 minutes have elapsed
Study Details
Timeline
Interventions
Bilateral proximal thigh bands that will be applied and inflated to a pressure of 80% of occlusive pressure as determined by the automated tourniquet before exercise. A standard exercise session would not include any blood occlusion.