At a glance
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Hemodynamic Effects of Fentanyl and Dexmedetomidine in Spine Surgery
In Brief
A Phase 4 clinical trial evaluating Dexmedetomidine and fentanyl for Spine Surgery and Hemodynamic Stability During Anesthesia. Completed, enrolled 50 participants across 1 site.
Detailed Summary
Researchers will compare dexmedetomidine to fentanyl to see which drug provides better hemodynamic stability during spinal surgery. Participants will : * Receive either dexmedetomidine or fentanyl as part of their anesthesia during elective surgery * Have their mean arterial pressure and heart rate measured at several time points during the procedure * Be monitored throughout surgery to assess intraoperative hemodynamic responses and stability
Study Details
Timeline
Interventions
Intravenous administration of dexmedetomidine at a dose of 0.5 μg/kgBW/hour during spinal surgery. Dexmedetomidine is a highly selective alpha-2 adrenergic agonist with sedative and analgesic properties. The aim is to evaluate its effect on maintaining hemodynamic stability, including mean arterial pressure (MAP) and heart rate, during and after anesthesia induction.
Intravenous administration of fentanyl at a dose of 1.5 μg/kgBW/hour during spinal surgery. Fentanyl is a potent synthetic opioid analgesic used to manage pain and modulate hemodynamic responses during surgery. This group serves as the comparator to evaluate differences in hemodynamic parameters, particularly MAP and heart rate, compared to dexmedetomidine.