CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 48 enrolled
Drug / intervention
Injectable Platelet-Rich Fibrin (i-PRF) +2 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07303192
NCT07303192N/ACompleted

The Effect of Injectable Platelet-Rich Fibrin and Low-Level Laser Therapy on Graft Shrinkage in Free Gingival Grafts: A Randomized Controlled Clinical Trial

Kahramanmaras Sutcu Imam University·interventional·Posted Dec 24, 2025·Updated Dec 24, 2025

In Brief

A clinical study evaluating Free Gingival Graft (FGG), Injectable Platelet-Rich Fibrin (i-PRF), and 1 other intervention for Graft Shrinkage and Gingival Recession, Localized. Completed, enrolled 48 participants across 1 site.

Detailed Summary

This randomized clinical trial aims to evaluate whether injectable platelet-rich fibrin (i-PRF) and low-level laser therapy (LLLT) can reduce graft shrinkage after free gingival graft procedures. Free gingival grafts are commonly used to increase the width of keratinized tissue around teeth, but the graft often shrinks during healing. In this study, patients will receive standard free gingival graft surgery with or without additional i-PRF or laser therapy. The goal is to determine whether these treatments improve healing and help maintain the size of the graft.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesTurkey (Türkiye)
Collaborators--

Timeline

N/ACompletedFinished
20252026
First PostedDec 24, 2025
Enrollment StartJul 1, 2024
Primary CompletionAug 30, 2025
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 6 months ago

Interventions

Free Gingival Graft (FGG)procedure

Standard free gingival graft procedure performed without additional treatments.

Injectable Platelet-Rich Fibrin (i-PRF)biological

Autologous platelet-rich fibrin gel is applied to the graft surface after free gingival graft surgery to potentially reduce graft shrinkage.

Low-Level Laser Therapy (LLLT)device

Low-level laser therapy is applied to the graft site immediately after surgery and on postoperative days 3, 5, 7, and 14 to potentially improve healing and reduce graft shrinkage.