CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 404 enrolled
Drug / intervention
To obtain bilateral ear photographs +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT07427745
NCT07427745N/ACompleted

PRESENCE OF FRANK'S SIGN: A COMPARATIVE EVALUATION IN SMOKERS AND NON-SMOKERS

Samsun University·observational·Posted Feb 23, 2026·Updated Feb 23, 2026

In Brief

An observational study evaluating To obtain bilateral ear photographs and To take a medical history for Smoking ( Cigarette) and Cardiovascular Disease. Completed, enrolled 404 participants across 1 site.

Detailed Summary

In this study, the effect of cigarette smoking-one of the major risk factors for cardiovascular diseases-on the development of Frank's sign (DELC) was investigated. Rather than smoking status alone, cumulative smoking exposure was considered to cause vascular damage and thereby influence the formation of DELC. Consequently, these findings may enable family physicians and other clinicians to approach patients rapidly and non-invasively within the framework of preventive medicine.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
CountriesTurkey (Türkiye)
Collaborators--

Timeline

N/ACompletedFinished
20252026
First PostedFeb 23, 2026
Enrollment StartSep 1, 2024
Primary CompletionMar 1, 2025
Study CompletionMay 6, 2025
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 4 months ago

Interventions

To obtain bilateral ear photographsother

Digital photographs obtained from both ears in a well-lit environment were evaluated by the study researchers. The presence of Frank's sign and its staging according to the Modified Patel-Lopez classification were confirmed by a positive assessment from at least two researchers

To take a medical historyother

The participants' sociodemographic data, histories of chronic diseases, medication use, family histories, and smoking habits were recorded by the researchers via face-to-face interviews (average duration: 5 min)