Comparison of Positive End-expiratory Pressure and Alveolar Recruitment Maneuver on Perioperative Oxygenation in Patients Undergoing Robotic Radical Prostatectomy: a Randomized Controlled Trial

Detailed Summary

The goal of this clinical trial is to determine whether different ventilatory strategies improve oxygenation and hemodynamic stability in patients undergoing robot-assisted radical prostatectomy under general anesthesia. The study will also evaluate the safety and physiological effects of applying positive end-expiratory pressure (PEEP) and alveolar recruitment maneuver (ARM) during surgery. The main questions this study aims to answer are: Does the application of PEEP or PEEP combined with ARM improve intraoperative oxygenation compared with conventional mechanical ventilation? How do PEEP and ARM affect intraoperative hemodynamic parameters such as cardiac output and stroke volume during pneumoperitoneum and steep Trendelenburg positioning? Are there any adverse events associated with the use of these ventilatory strategies during surgery? Researchers will compare three ventilation strategies-conventional ventilation without PEEP, ventilation with PEEP alone, and ventilation with PEEP combined with ARM-to evaluate their effects on perioperative oxygenation and cardiovascular function. Participants will: Undergo robot-assisted radical prostatectomy under general anesthesia Be randomly assigned to receive one of three ventilatory strategies during surgery Receive standardized anesthetic management and intraoperative monitoring Have arterial blood gas analysis and hemodynamic measurements performed at predefined time points during surgery and recovery

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Interventions